Covid-19 origins: WHO addresses new evidence from China


There’s a tantalizing new clue within the hunt for the origins of the Covid-19 pandemic.

A brand new evaluation of genetic materials collected from January to March 2020 on the Huanan Seafood Market in Wuhan, China, has uncovered animal DNA in samples already identified to be constructive for SARS-CoV-2, the coronavirus that causes Covid-19. A big quantity of that DNA seems to belong to animals generally known as raccoon canine, which had been identified to be traded on the market, based on officers with the World Well being Group, who addressed the brand new proof in a information briefing on Friday.

The connection to raccoon canine got here to gentle after Chinese language researchers shared uncooked genetic sequences taken from swabbed specimens collected on the market early within the pandemic. The sequences had been uploaded in late January 2023, to the info sharing web site GISAID, however have just lately been eliminated.

A global staff of researchers observed them and downloaded them for additional research, the WHO officers stated Friday.

The brand new findings – which haven’t but been publicly posted – don’t settle the query of how the pandemic began. They don’t show that raccoon canine had been contaminated with SARS-CoV-2, nor do they show that raccoon canine had been the animals that first contaminated individuals.

However as a result of viruses don’t survive within the setting outdoors of their hosts for lengthy, discovering a lot of the genetic materials from the virus intermingled with genetic materials from raccoon canine is very suggestive that they might have been carriers, based on scientists who labored on the evaluation. The evaluation was led by Kristian Andersen, an immunologist and microbiologist at Scripps Analysis; Edward Holmes, a virologist on the College of Sydney; Michael Worobey, an evolutionary biologist on the College of Arizona. These three scientists, who’ve been digging into the origins of the pandemic, had been interviewed by reporters for The Atlantic journal. CNN has reached out to Andersen, Holmes and Worobey for remark.

The main points of the worldwide evaluation had been first reported Thursday by The Atlantic.

The brand new knowledge is rising as Republicans in Congress have opened investigations into the pandemic’s origin. Earlier research offered proof that the virus possible emerged naturally in market, however couldn’t level to a selected origin. Some US companies, together with a current US Division of Power evaluation, say the pandemic possible resulted from a lab leak in Wuhan.

Within the information briefing on Friday, WHO Director-Common Tedros Adhanom Ghebreyesus stated the group was first made conscious of the sequences on Sunday.

“As quickly as we turned conscious of this knowledge, we contacted the Chinese language CDC and urged them to share it with WHO and the worldwide scientific neighborhood so it may be analyzed,” Tedros stated.

WHO additionally convened its Scientific Advisory Group for the Origins of the Novel Pathogens, generally known as SAGO, which has been investigating the roots of the pandemic, to debate the info on Tuesday. The group heard from Chinese language scientists who had initially studied the sequences, in addition to the group of worldwide scientists taking a recent take a look at them.

WHO consultants stated within the Friday briefing that the info aren’t conclusive. They nonetheless can’t say whether or not the virus leaked from a lab, or if it spilled over naturally from animals to people.

“These knowledge don’t present a definitive reply to the query of how the pandemic started, however each piece of information is essential in shifting us nearer to that reply,” Tedros stated.

What the sequences do show, WHO officers stated, is that China has extra knowledge that may relate to the origins of the pandemic that it has not but shared with the remainder of the world.

“This knowledge might have, and may have, been shared three years in the past,” Tedros stated. “We proceed to name on China to be clear in sharing knowledge and to conduct the mandatory investigations and share outcomes.

“Understanding how the pandemic started stays an ethical and scientific crucial.”

CNN has reached out to the Chinese language scientists who first analyzed and shared the info, however has not obtained a reply.

The Chinese language researchers, who’re affiliated with that nation’s Middle for Illness Management and Prevention, had shared their very own evaluation of the samples in 2022. In that preprint research posted final 12 months, they concluded that “no animal host of SARS-CoV2 might be deduced.”

The analysis checked out 923 environmental samples taken from throughout the seafood market and 457 samples taken from animals, and located 63 environmental samples that had been constructive for the virus that causes Covid-19. Most had been taken from the western finish of the market. Not one of the animal samples, which had been taken from refrigerated and frozen merchandise on the market, and from reside, stray animals roaming the market, had been constructive, the Chinese language authors wrote in 2022.

After they appeared on the completely different species of DNA represented within the environmental samples, the Chinese language authors solely noticed a hyperlink to people, however not different animals.

When a global staff of researchers just lately took at recent take a look at the genetic materials within the samples – which had been swabbed in and across the stalls of the market – utilizing a complicated genetic method known as metagenomics, scientists stated they had been stunned to discover a important quantity of DNA belonging to raccoon canine, a small animal associated to foxes. Raccoon canine might be contaminated with the virus that causes Covid-19 and have been excessive on the listing of suspected animal hosts for the virus.

“What they discovered is molecular proof that animals had been offered at that market. That was suspected, however they discovered molecular proof of that. And in addition that a number of the animals that had been there have been inclined to SARS-CoV2 an infection, and a few of these animals embody raccoon canine,” stated Maria Van Kerkhove, WHO’s technical lead for Covid-19, in Friday’s briefing.

“This doesn’t change our method to finding out the origins of Covid-19. It simply tells us that extra knowledge exists, and that knowledge must be shared in full,” she stated.

Van Kerkhove stated that till the worldwide scientific neighborhood is ready to overview extra proof, “all hypotheses stay on the desk.”

Some consultants discovered the brand new proof persuasive, if not utterly convincing, of an origin available in the market.

“The info does level even additional to a market origin,” Andersen, the Scripps Analysis evolutionary biologist who attended the WHO assembly and is likely one of the scientists analyzing the brand new knowledge, informed the journal Science.

The assertions revamped the brand new knowledge rapidly sparked debate within the scientific neighborhood.

Francois Balloux, director of the Genetics Institute at College School London, stated the truth that the brand new evaluation had not but been publicly posted for scientists to scrutinize, however had come to gentle in information studies, warranted warning.

“Such articles actually don’t assist as they solely polarise the talk additional,” Balloux posted in a thread on Twitter. “These satisfied by a zoonotic origin will learn it as ultimate proof for his or her conviction, and people satisfied it was a lab leak will interpret the weak point of the proof as makes an attempt of a cover-up.”

Different consultants, who weren’t concerned within the evaluation, stated the info could possibly be key to exhibiting the virus had a pure origin.

Felicia Goodrum is an immunobiologist on the College of Arizona, who just lately printed a overview of all obtainable knowledge for the assorted theories behind the pandemic’s origin.

Goodrum says the strongest proof for a pure spillover could be to isolate the virus that causes Covid-19 from an animal that was current available in the market in 2019.

“Clearly, that’s inconceivable, as we can’t return in time any greater than we now have via sequencing, and no animals had been current on the time sequences could possibly be collected. To me, that is the following neatest thing,” Goodrum stated in an electronic mail to CNN.

Within the WHO briefing, Van Kerkhove stated that the Chinese language CDC researchers had uploaded the sequences to GISAID as they had been updating their authentic analysis. She stated their first paper is within the technique of being up to date and resubmitted for publication.

“Now we have been informed by GISAID that the info from China’s CDC is being up to date and expanded,” she stated.

Van Kerkhove stated on Friday that what WHO would love to have the ability to do is to search out the supply of the place the animals got here from. Have been they wild? Have been they farmed?

She stated in the middle of its investigation into the pandemic’s origins, WHO had repeatedly requested China for research to hint the animals again to their supply farms. She stated WHO had additionally requested for blood checks on individuals who labored available in the market, in addition to checks on animals that will have come from the farms.

“Share the info,” Dr. Mike Ryan, govt director of WHO’s well being emergencies program, stated Friday, addressing scientists all over the world who might need related data. “Let science do the work, and we are going to get the solutions.”